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Experimental drug may help with long-term TBI damage

People in Ohio with traumatic brain injury might be interested in a new study testing drugs that improve healing in mice with TBI. While symptoms of TBI in the weeks and months after an injury may include dizziness, poor concentration, headaches, fatigue and more, there is also concern that a TBI can lead to long-term complications. One study found that people who had TBIs months or years earlier developed the same brain plaques as those seen in Alzheimer's patients.

Researchers published a study in "PLOS One" that examined a drug called MW151 and its effect on mice. This was a follow-up to a previous study in which MW151 was found to reduce inflammation, maintain immune cells and improve cognitive skills. This study tested a more severe type of TBI and found similar results. The drug reduced inflammation but did not interfere with healing.

Researchers say that MW151 could represent the first treatment for long-term TBI complications such as epilepsy, neuropsychiatric disorders, increased dementia risk and more. They hope that within the next several years the drug can be tested on human subjects.

A brain injury may occur due to an automobile accident, a fall, an assault or while playing sports among other causes. Its symptoms may be resolves over a few weeks or may continue for a long time, and even in cases when the initial symptoms do not linger, there may be damage that does not surface for years. It is possible that a person might not realize the severity of the injury until days or weeks later. If another party is liable in the accident that causes the TBI, the injured person may want to file a lawsuit against them. For example, a fall may occur at a retail establishment because of wet floors or objects left on the floor in an aisle.

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